Expresión de búsqueda:
POLY(A)-BINDING PROTEIN II
Descriptores Encontrados:
1
Mostrando:
1 .. 1
1 / 1
DeCS
Descriptor
Inglés
:
Poly(A)-Binding Protein II
Descriptor
Español
:
Proteína II de Unión a Poli(A)
Descriptor
Portugués
:
Proteína II de Ligação a Poli(A)
Categoría:
D12.776.157.725.452.500
D12.776.664.962.452.500
Definición
Inglés
:
A poly(A) binding protein that is involved in promoting the extension of the
poly A
tails of MRNA. The protein requires a minimum of ten
ADENOSINE
nucleotides
in order for binding to mRNA. Once bound it works in conjunction with
CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR
to stimulate the rate of
poly A
synthesis by
POLY A
POLYMERASE. Once poly-A tails reach around 250
nucleotides
in length poly(A) binding protein II no longer stimulates
POLYADENYLATION
. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the
disease
MUSCULAR DYSTROPHY
, OCULOPHARYNGEAL.
Relacionados
Inglés
:
Muscular Dystrophy, Oculopharyngeal
Nota Histórica
Inglés
:
2003; for PAB II use POLY(A)-BINDING PROTEINS (NM) 1995-2002; for PABP2 GENE PRODUCT & PABP2 PROTEIN use POLY(A)-BINDING PROTEINS (NM) 1999-2002; for PABP2 use POLY(A)-BINDING PROTEINS (NM) 2000-2002
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
37408
Identificador Único:
D039103
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS